TDP2

Across TCGA patient cohorts, TDP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDP2-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and STAT3_pY705. Each is linked with TDP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDP2-to-partner and partner-to-TDP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TDP2-low versus TDP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP2→partner) and Y-score (partner→TDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.250	+2.183	.043	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.529	-3.000	.024	.036	3	1
UCEC	STAT3_pY705 →	-0.520	-2.999	<.001	.035	3	1
UCEC	mTOR →	-0.258	-3.000	.002	.036	2	1
UCEC	Notch1 →	+0.297	+3.321	<.001	.010	1	1
UCEC	Rab25 →	-0.539	-3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by TDP2 expression — UCEC

Explore this box plot interactively →