TDP2

Across TCGA cell cohorts, TDP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TDP2-associated GO terms across cancer lineages are Import into nucleus, Protein localization to nucleus, and Negative regulation of RNA export from nucleus. Each is linked with TDP2 in more than 10 cancer types. Because this analysis shows association rather than direction, both TDP2-to-partner and partner-to-TDP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Import into nucleus grouped by TDP2-low versus TDP2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP2→partner) and Y-score (partner→TDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Import into nucleus →	+0.054	+0.544	<.001	<.001	3	11
BLOOD_Leukemia	Protein localization to nucleus →	+0.043	+0.550	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Negative regulation of RNA export from nucleus →	+0.163	+1.558	.007	.005	2	10
BLOOD_Lymphoma	Protein import into nucleus →	+0.064	+0.749	<.001	<.001	3	9
BLOOD_Myeloma	Negative regulation of G2/M transition of mitotic cell cycle →	+0.059	+0.626	.004	.001	3	9
BLOOD_Myeloma	Negative regulation of cell cycle G2/M phase transition →	+0.060	+0.643	.005	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,120 associations by consensus.

Import into nucleus by TDP2 expression — BREAST

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