TDP1

Across TCGA patient cohorts, TDP1 mutation is significantly associated with the RNA expression of many other genes, with 2,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDP1-associated genes across cancer lineages are EIF4A1P3, MIR6803, and RNA5SP129. Each is linked with TDP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TDP1-to-partner and partner-to-TDP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4A1P3 grouped by TDP1-low versus TDP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP1→partner) and Y-score (partner→TDP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4A1P3 →	+0.274	+3.993	<.001	.005	3	3
UCEC	MIR6803 →	+0.098	+4.156	<.001	.004	3	2
BLCA	RNA5SP129 →	+0.303	+3.343	.006	.007	3	2
UCEC	CENPU →	+0.747	+2.850	<.001	.001	3	2
UCEC	CENPH →	+0.591	+2.180	.001	.002	3	2
UCEC	CHAF1B →	+0.686	+3.103	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,229 associations by consensus.

EIF4A1P3 by TDP1 expression — COAD

Explore this box plot interactively →