TDG

Across TCGA pan-cancer cohorts, TDG mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TDG data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TDG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TDG expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where TDG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.426	0.759	.015	18	view →
LSCC	OS	Tertile	II,III,IV	0.948	0.551	.004	10	view →
LUAD	DFS	Quartile	II,III,IV	0.971	0.588	.005	10	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.612	.037	8	view →
CCRCC	OS	Median	II,III,IV	0.916	0.604	.030	5	view →
GBM	DFS	Median	All	0.757	0.567	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TDG–HNSC (DFS)

Open the HNSC breakdown →