TDG

Across TCGA patient cohorts, TDG mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDG-associated genes across cancer lineages are MIR3612, TRIM49D1, and RNU6-782P. Each is linked with TDG in more than 2 cancer types. Because this analysis shows association rather than direction, both TDG-to-partner and partner-to-TDG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3612 grouped by TDG-low versus TDG-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDG→partner) and Y-score (partner→TDG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR3612 →	+0.320	+7.930	<.001	.008	3	3
LUAD	TRIM49D1 →	+0.014	+7.930	<.001	.008	3	2
SKCM	RNU6-782P →	+0.238	+4.614	<.001	.006	3	2
LGG	RNU6-383P →	+0.368	+7.977	<.001	.007	3	2
LGG	RN7SL379P →	+0.139	+7.977	<.001	.007	3	2
BLCA	RN7SL565P →	+0.209	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

MIR3612 by TDG expression — LUAD

Explore this box plot interactively →