TDG

Across TCGA cell cohorts, TDG RNA expression is significantly associated with the go_rna of many other GO terms, with 5,495 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TDG-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Nuclear pore complex assembly, and Negative regulation of transcription by RNA polymerase I. Each is linked with TDG in more than 19 cancer types. Because this analysis shows association rather than direction, both TDG-to-partner and partner-to-TDG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by TDG-low versus TDG-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDG→partner) and Y-score (partner→TDG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.242	+1.103	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.153	+0.961	.001	.002	3	15
LARGE_INTESTINE	Negative regulation of transcription by RNA polymerase I →	+0.150	+1.029	<.001	<.001	3	15
LUNG_SCLC	Regulation of DNA-templated transcription elongation →	+0.061	+0.883	<.001	<.001	3	15
LUNG_SCLC	DNA-templated DNA replication maintenance of fidelity →	+0.112	+0.821	<.001	<.001	3	15
BONE	Regulation of DNA repair →	+0.072	+0.832	.003	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,495 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by TDG expression — LARGE_INTESTINE

Explore this box plot interactively →