TDG

Across TCGA cell cohorts, TDG mutation is significantly associated with the mutation status of many other genes, with 2,956 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDG-associated genes across cancer lineages are NR1D1, SP110, and POLA1. Each is linked with TDG in more than 3 cancer types. Because this analysis shows association rather than direction, both TDG-to-partner and partner-to-TDG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NR1D1 grouped by TDG-low versus TDG-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDG→partner) and Y-score (partner→TDG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NR1D1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Leukemia	SP110 →	+4.736	+5.560	.003	.003	1	4
BLOOD_Lymphoma	POLA1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	FNDC3A →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	ATF2 →	+6.321	+6.321	.001	.001	1	3
BLOOD_Lymphoma	HSPA2 →	+5.014	+5.584	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,956 associations by consensus.

NR1D1 by TDG expression — BLOOD_Lymphoma

Explore this box plot interactively →