Across TCGA cell cohorts, TCTN1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCTN1-associated genes across cancer lineages are LORICRIN, USP17L18, and MT4. Each is linked with TCTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTN1-to-partner and partner-to-TCTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTN1→partner) and Y-score (partner→TCTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LORICRIN →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L18 →	+0.006	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MT4 →	+3.277	+3.556	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.095	+4.345	<.001	<.001	3	1
LARGE_INTESTINE	C10orf53 →	+0.016	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TCTN1 survival (RNA) · tumor vs normal (RNA) · all TCTN1 data types