TCTA

Across TCGA patient cohorts, TCTA mutation is significantly associated with the RNA expression of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTA-associated genes across cancer lineages are RNU6-1089P, RNU6ATAC42P, and RN7SL495P. Each is linked with TCTA in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTA-to-partner and partner-to-TCTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1089P grouped by TCTA-low versus TCTA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTA→partner) and Y-score (partner→TCTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1089P →	+0.640	+5.081	.002	.008	3	2
SKCM	RNU6ATAC42P →	+0.544	+5.594	<.001	.004	3	2
UCEC	RN7SL495P →	+0.388	+6.335	<.001	.001	3	1
BLCA	LINC02349 →	+0.070	+5.329	.004	.006	3	1
BLCA	RN7SL178P →	+0.279	+5.899	<.001	.002	3	1
BLCA	COX6CP16 →	+0.264	+5.177	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

RNU6-1089P by TCTA expression — UCEC

Explore this box plot interactively →