TCP11L2

Across TCGA patient cohorts, TCP11L2 mutation is significantly associated with the RNA expression of many other genes, with 3,054 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP11L2-associated genes across cancer lineages are RNU6-18P, NPAP1P7, and COX15. Each is linked with TCP11L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCP11L2-to-partner and partner-to-TCP11L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-18P grouped by TCP11L2-low versus TCP11L2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11L2→partner) and Y-score (partner→TCP11L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-18P →	+0.351	+5.468	<.001	.002	3	3
OV	NPAP1P7 →	+0.049	+4.676	<.001	.007	3	2
UCEC	COX15 →	+0.482	+2.671	<.001	<.001	3	2
UCEC	MTA2 →	+0.310	+2.158	.005	.009	3	2
UCEC	CPSF7 →	+0.329	+2.119	.002	.002	3	2
UCEC	FAM177A1 →	+0.332	+3.939	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,054 associations by consensus.

RNU6-18P by TCP11L2 expression — HNSC

Explore this box plot interactively →