TCP11L2

Across TCGA pan-cancer cohorts, TCP11L2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TCP11L2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TCP11L2 RNA is repressed in tumor relative to normal tissue. In most cancer types TCP11L2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and HNSC are the cancer types where TCP11L2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCP11L2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.214	<.001	9	view →
LUAD	Female	III,IV	−1.506	<.001	8	view →
HNSC	Male	All	−0.826	<.001	8	view →
BRCA	All	III,IV	−0.709	<.001	6	view →
THCA	Female	All	−0.665	<.001	6	view →
READ	All	All	−0.659	.003	5	view →
UCEC	All	All	−0.917	<.001	4	view →
CHOL	All	All	+1.174	<.001	3	view →
COAD	Female	III,IV	−0.726	.036	2	view →
STAD	All	All	−0.638	.046	1	view →
KIRP	All	II,III,IV	+0.551	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TCP11L2–LUSC

Open the LUSC breakdown →