TCP11L2

Across TCGA patient cohorts, TCP11L2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP11L2-associated genes across cancer lineages are PCNA, EGFR, and eIF4E. Each is linked with TCP11L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP11L2-to-partner and partner-to-TCP11L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TCP11L2-low versus TCP11L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11L2→partner) and Y-score (partner→TCP11L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.242	+2.321	.002	.005	3	2
UCEC	EGFR →	-0.165	-2.973	.005	.035	3	1
UCEC	eIF4E →	+0.215	+2.247	.005	.001	3	1
UCEC	Fibronectin →	-0.247	-1.990	.041	.009	3	1
UCEC	FoxM1 →	+0.205	+1.502	.031	.030	3	1
UCEC	GSK3-a-b →	-0.118	-2.321	.017	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by TCP11L2 expression — UCEC

Explore this box plot interactively →