TCP11L2

Across TCGA cell cohorts, TCP11L2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCP11L2-associated genes across cancer lineages are GZMK, OCM2, and GPR6. Each is linked with TCP11L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP11L2-to-partner and partner-to-TCP11L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by TCP11L2-low versus TCP11L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11L2→partner) and Y-score (partner→TCP11L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GZMK →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OCM2 →	+0.055	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPR6 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GZMK by TCP11L2 expression — LARGE_INTESTINE

Explore this box plot interactively →