Across TCGA patient cohorts, TCP10L3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP10L3-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ACC_pS79. Each is linked with TCP10L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP10L3-to-partner and partner-to-TCP10L3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP10L3→partner) and Y-score (partner→TCP10L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-2.301	.023	.034	3	1
UCEC	A-Raf_pS299 →	-0.171	-3.700	<.001	.001	3	1
UCEC	ACC_pS79 →	+0.315	+1.807	.027	.027	3	1
UCEC	p27_pT157 →	-0.053	-3.420	.026	.005	3	1
UCEC	p90 RSK →	+0.161	+3.009	.042	.019	3	1
UCEC	PCNA →	+0.210	+2.321	.018	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TCP10L3 survival (RNA) · tumor vs normal (RNA) · all TCP10L3 data types