TCP10L2

Across TCGA patient cohorts, TCP10L2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP10L2-associated genes across cancer lineages are FoxM1, Notch1, and p70-S6K. Each is linked with TCP10L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP10L2-to-partner and partner-to-TCP10L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TCP10L2-low versus TCP10L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP10L2→partner) and Y-score (partner→TCP10L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.287	+2.999	.043	.035	3	1
UCEC	Notch1 →	+0.261	+3.169	<.001	.020	3	1
UCEC	p70-S6K →	+0.227	+3.196	.031	.010	3	1
UCEC	eIF4E →	+0.229	+3.169	.048	.020	2	1
UCEC	Caspase-8 →	-0.365	-3.169	.008	.020	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.735	+3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by TCP10L2 expression — UCEC

Explore this box plot interactively →