TCP10L2

Across TCGA pan-cancer cohorts, TCP10L2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TCP10L2 data layer compared with 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TCP10L2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TCP10L2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, LGG, and HNSC are the cancer types where TCP10L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.582	0.291	.001	47	view →
LGG	OS	Median	All	0.838	0.922	<.001	45	view →
HNSC	DFS	Quartile	III,IV	0.492	0.261	.003	43	view →
UCEC	DFS	Median	All	0.531	0.739	.004	22	view →
LUSC	DFS	Quartile	II,III,IV	0.312	0.724	.002	15	view →
KIRP	OS	Median	II,III,IV	0.908	0.363	.015	14	view →
TGCT	DFS	Median	II,III,IV	0.737	0.996	.035	12	view →
ACC	DFS	Tertile	III,IV	0.080	0.413	.046	9	view →
LIHC	OS	Tertile	III,IV	0.507	0.749	.012	8	view →
BLCA	DFS	Quartile	IV	0.343	0.496	.019	6	view →
READ	DFS	Tertile	IV	0.429	0.889	.017	6	view →
THCA	OS	Tertile	IV	1.000	0.589	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TCP10L2–LUAD (OS)

Open the LUAD breakdown →