TCP10L

Across TCGA pan-cancer cohorts, TCP10L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TCP10L data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TCP10L RNA is associated with better overall survival. In most high-consensus cancer types, elevated TCP10L expression acts as an unfavorable survival marker, although some lineages such as UVM and LIHC show a favorable association.

UVM, COAD, and LIHC are the cancer types where TCP10L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	III,IV	0.955	0.402	.001	70	view →
COAD	DFS	Median	III,IV	0.242	0.529	<.001	69	view →
LIHC	OS	Tertile	All	0.770	0.583	<.001	36	view →
DLBC	DFS	Median	II,III,IV	0.168	1.000	<.001	33	view →
ACC	DFS	Tertile	IV	0.630	0.107	.001	25	view →
MESO	DFS	Quartile	III,IV	0.309	0.599	.004	24	view →
READ	DFS	Tertile	III,IV	0.623	0.876	.014	15	view →
UCS	OS	Tertile	IV	0.263	0.761	.036	12	view →
CHOL	DFS	Quartile	All	0.175	0.648	.019	11	view →
SCLC	DFS	Tertile	II,III,IV	1.000	0.250	.006	11	view →
SKCM	OS	Quartile	IV	0.856	0.552	.032	10	view →
THYM	DFS	Tertile	III,IV	0.442	1.000	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TCP10L–UVM (OS)

Open the UVM breakdown →