TCP10L

Across TCGA pan-cancer cohorts, TCP10L RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TCP10L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TCP10L RNA is repressed in tumor relative to normal tissue. In most cancer types TCP10L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where TCP10L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCP10L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.736	<.001	11	view →
THCA	Male	All	−0.345	<.001	11	view →
LIHC	Female	All	−1.004	<.001	4	view →
BRCA	All	All	+0.182	<.001	4	view →
CHOL	All	All	−0.943	<.001	2	view →
UCEC	All	III,IV	−0.425	.006	2	view →
BLCA	All	IV	−0.251	.027	2	view →
PAAD	All	All	+0.144	.036	2	view →
LUSC	All	III,IV	−0.226	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TCP10L–KICH

Open the KICH breakdown →