TCOF1

Across TCGA cell cohorts, TCOF1 mutation is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCOF1-associated genes across cancer lineages are ALDH6A1, APOA5, and MYH13. Each is linked with TCOF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCOF1-to-partner and partner-to-TCOF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDH6A1 grouped by TCOF1-low versus TCOF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCOF1→partner) and Y-score (partner→TCOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH6A1 →	+1.189	+3.234	<.001	.004	3	2
OESOPHAGUS	APOA5 →	+0.013	+4.017	.002	.007	3	1
OESOPHAGUS	MYH13 →	+0.039	+4.017	<.001	.007	3	1
KIDNEY	OR5B12 →	+0.033	+3.584	.005	.004	3	1
KIDNEY	PTPRT →	+0.062	+3.222	<.001	.004	3	1
BLOOD_Lymphoma	OR10J1 →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

ALDH6A1 by TCOF1 expression — LARGE_INTESTINE

Explore this box plot interactively →