TCIM

Across TCGA patient cohorts, TCIM protein abundance is significantly associated with the RNA expression of many other genes, with 7,159 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TCIM-associated genes across cancer lineages are SERPINA3, WFDC2, and NCOA7. Each is linked with TCIM in more than 2 cancer types. Because this analysis shows association rather than direction, both TCIM-to-partner and partner-to-TCIM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TCIM versus SERPINA3 in GBM, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCIM→partner) and Y-score (partner→TCIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINA3 →	+1.859	+0.653	.002	.004	3	3
LSCC	WFDC2 →	+1.483	+0.580	<.001	<.001	3	2
LUAD	NCOA7 →	+0.587	+0.432	.003	<.001	3	2
LSCC	ITGB6 →	+1.292	+0.490	<.001	<.001	3	2
LUAD	BMP2 →	+1.127	+0.433	.001	.004	3	2
LSCC	CHIA →	+0.833	+0.624	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,159 associations by consensus.

TCIM vs SERPINA3 — GBM

Explore this scatter interactively →