TCIM

Across TCGA patient cohorts, TCIM mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCIM-associated genes across cancer lineages are TIGAR, p53, and XRCC1. Each is linked with TCIM in more than 1 cancer types. Because this analysis shows association rather than direction, both TCIM-to-partner and partner-to-TCIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by TCIM-low versus TCIM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCIM→partner) and Y-score (partner→TCIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.228	+1.901	.001	.031	3	2
SKCM	p53 →	-0.238	-2.982	.026	.036	3	1
SKCM	XRCC1 →	+0.223	+3.000	.027	.036	3	1
UCEC	Annexin-1 →	+0.821	+3.700	<.001	.001	3	1
UCEC	Stathmin →	+0.128	+3.000	.045	.036	3	1
UCEC	ATM →	-0.444	-3.000	.035	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TIGAR by TCIM expression — UCEC

Explore this box plot interactively →