TCHHL1

Across TCGA patient cohorts, TCHHL1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCHHL1-associated genes across cancer lineages are MEK1, PCNA, and Shc_pY317. Each is linked with TCHHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCHHL1-to-partner and partner-to-TCHHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TCHHL1-low versus TCHHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCHHL1→partner) and Y-score (partner→TCHHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.433	+3.087	.001	<.001	3	3
UCEC	PCNA →	+0.180	+1.847	.023	.008	3	3
UCEC	Shc_pY317 →	-0.165	-1.584	.003	.034	3	3
UCEC	INPP4B →	-0.338	-2.700	.004	.005	3	2
UCEC	Src →	-0.238	-2.247	.001	.001	3	2
UCEC	EGFR →	-0.191	-1.807	.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MEK1 by TCHHL1 expression — UCEC

Explore this box plot interactively →