TCFL5

Across TCGA pan-cancer cohorts, TCFL5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TCFL5 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TCFL5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TCFL5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where TCFL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.104	0.985	.014	28	view →
LSCC	DFS	Median	All	0.551	0.843	.003	20	view →
PDAC	OS	Quartile	All	0.804	1.000	.024	6	view →
HNSC	DFS	Median	IV	0.867	0.578	.007	5	view →
LUAD	OS	Median	All	1.000	0.959	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TCFL5–CCRCC (OS)

Open the CCRCC breakdown →