TCFL5

Across TCGA pan-cancer cohorts, TCFL5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TCFL5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TCFL5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TCFL5 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where TCFL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCFL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.259	<.001	12	view →
COAD	Female	II,III,IV	+1.292	<.001	11	view →
KIRC	Female	II,III,IV	−0.629	<.001	11	view →
THCA	Male	III,IV	−1.192	<.001	10	view →
LIHC	Male	All	+1.084	<.001	9	view →
LUAD	Male	All	+0.553	<.001	9	view →
LUSC	Female	All	+0.998	<.001	7	view →
BRCA	All	II,III,IV	+0.311	<.001	6	view →
CHOL	Female	All	+1.790	<.001	5	view →
UCEC	All	All	−0.601	.001	4	view →
STAD	All	II,III,IV	+0.741	.008	3	view →
KIRP	Male	II,III,IV	+0.469	.029	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TCFL5–HNSC

Open the HNSC breakdown →