TCF7L1-IT1

Across TCGA pan-cancer cohorts, TCF7L1-IT1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated TCF7L1-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TCF7L1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCF7L1-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

KIRC, ACC, and MESO are the cancer types where TCF7L1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.149	0.445	<.001	62	view →
ACC	OS	Tertile	All	0.128	0.706	<.001	48	view →
MESO	DFS	Tertile	All	0.281	0.443	.008	45	view →
UCS	OS	Quartile	III,IV	0.938	0.468	.005	42	view →
STAD	OS	Tertile	II,III,IV	0.354	0.611	.004	27	view →
THCA	OS	Quartile	All	0.949	0.992	.005	22	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	21	view →
COAD	DFS	Tertile	IV	0.089	0.494	<.001	18	view →
BRCA	DFS	Median	IV	0.339	0.704	.009	17	view →
GBM	OS	Median	All	0.248	0.154	.016	9	view →
LGG	OS	Quartile	All	0.977	0.854	.001	8	view →
THYM	DFS	Median	II,III,IV	0.941	0.787	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

TCF7L1-IT1–KIRC (DFS)

Open the KIRC breakdown →