TCF7L1-IT1

Across TCGA pan-cancer cohorts, TCF7L1-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TCF7L1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TCF7L1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types TCF7L1-IT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where TCF7L1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCF7L1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.308	<.001	9	view →
KICH	All	All	−0.182	<.001	6	view →
KIRC	Male	III,IV	−0.065	.016	6	view →
LUSC	Female	III,IV	−0.210	.002	5	view →
KIRP	All	All	−0.108	.007	5	view →
BRCA	All	III,IV	−0.254	.002	4	view →
LUAD	Female	II,III,IV	−0.204	.002	1	view →
COAD	Female	All	−0.037	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TCF7L1-IT1–THCA

Open the THCA breakdown →