TCF7

Across TCGA patient cohorts, TCF7 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,583 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TCF7-associated proteins across cancer lineages are PSIP1, ZMAT2, and LMNB1. Each is linked with TCF7 in more than 5 cancer types. Because this analysis shows association rather than direction, both TCF7-to-partner and partner-to-TCF7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TCF7 versus PSIP1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7→partner) and Y-score (partner→TCF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSIP1 →	+0.648	+0.577	<.001	<.001	3	6
LSCC	ZMAT2 →	+0.241	+0.426	.002	<.001	3	5
GBM	LMNB1 →	+0.286	+0.412	<.001	<.001	3	5
GBM	SP4 →	+0.524	+0.489	.001	<.001	3	4
GBM	THYN1 →	+0.503	+0.623	<.001	<.001	3	4
HNSC	NR2C2 →	+0.210	+0.333	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,583 associations by consensus.

TCF7 vs PSIP1 — GBM

Explore this scatter interactively →