TCF4-AS2

Across TCGA pan-cancer cohorts, TCF4-AS2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated TCF4-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TCF4-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TCF4-AS2 expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

KIRC, ACC, and LIHC are the cancer types where TCF4-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.395	0.593	<.001	129	view →
ACC	OS	Tertile	All	0.503	0.896	<.001	120	view →
LIHC	DFS	Tertile	All	0.098	0.538	<.001	42	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	39	view →
CESC	OS	Tertile	IV	0.149	0.614	.002	36	view →
THCA	OS	Tertile	All	0.982	0.994	.003	18	view →
OV	OS	Tertile	IV	0.305	0.765	.016	18	view →
UCEC	OS	Tertile	All	0.813	0.883	.040	18	view →
SKCM	DFS	Tertile	IV	0.016	0.541	.008	9	view →
PAAD	DFS	Tertile	All	0.270	0.481	.029	9	view →
STAD	OS	Quartile	IV	0.860	0.256	.016	6	view →
HNSC	OS	Tertile	IV	0.807	0.687	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

TCF4-AS2–KIRC (OS)

Open the KIRC breakdown →