TCF4-AS2

Across TCGA pan-cancer cohorts, TCF4-AS2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TCF4-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TCF4-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types TCF4-AS2 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and LUSC are the cancer types where TCF4-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCF4-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.067	.003	8	view →
BRCA	All	III,IV	−0.074	.004	2	view →
LUSC	Female	All	−0.065	.013	1	view →
KICH	All	All	−0.040	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TCF4-AS2–THCA

Open the THCA breakdown →