TCF25

Across TCGA patient cohorts, TCF25 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF25-associated genes across cancer lineages are IGFBP2, eEF2, and A-Raf_pS299. Each is linked with TCF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF25-to-partner and partner-to-TCF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by TCF25-low versus TCF25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF25→partner) and Y-score (partner→TCF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.523	-1.392	.014	.019	3	2
UCEC	eEF2 →	+0.312	+1.874	.008	.049	3	2
UCEC	A-Raf_pS299 →	-0.168	-2.999	<.001	<.001	3	2
UCEC	ERK2 →	+0.221	+3.906	<.001	<.001	3	2
UCEC	ACC1 →	+0.247	+1.887	.039	.029	3	2
UCEC	MSH2 →	-0.293	-2.880	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

IGFBP2 by TCF25 expression — UCEC

Explore this box plot interactively →