TCF25

Across TCGA pan-cancer cohorts, TCF25 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TCF25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TCF25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TCF25 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where TCF25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCF25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.514	<.001	12	view →
KIRP	All	II,III,IV	+0.462	.001	9	view →
LIHC	Female	II,III,IV	+0.782	<.001	8	view →
THCA	Male	IV	−0.383	.002	8	view →
CHOL	All	All	+1.374	<.001	5	view →
KICH	All	All	−0.601	<.001	5	view →
STAD	Male	II,III,IV	+0.553	.001	5	view →
BLCA	Male	III,IV	−0.605	.004	4	view →
UCEC	All	All	−0.472	.010	4	view →
BRCA	Female	II,III,IV	−0.355	<.001	4	view →
LUSC	Male	All	−0.196	.027	2	view →
HNSC	All	All	+0.208	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TCF25–KIRC

Open the KIRC breakdown →