TCF25

Across TCGA cell cohorts, TCF25 mutation is significantly associated with the protein abundance of many other proteins, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TCF25-associated proteins across cancer lineages are ACAD9, THOC3, and ACAT1. Each is linked with TCF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF25-to-partner and partner-to-TCF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACAD9 grouped by TCF25-low versus TCF25-high in BLOOD_Leukemia.

mutation associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF25→partner) and Y-score (partner→TCF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACAD9 →	-0.617	-3.212	.002	.007	3	1
BLOOD_Leukemia	THOC3 →	+0.333	+3.321	.006	.006	3	1
BLOOD_Leukemia	ACAT1 →	-0.876	-3.285	.001	.006	3	1
BLOOD_Leukemia	THOC1 →	+0.354	+3.321	.007	.006	3	1
BLOOD_Leukemia	DHRS7 →	-1.008	-3.321	<.001	.006	3	1
BLOOD_Leukemia	ZNF428 →	+1.094	+3.359	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

ACAD9 by TCF25 expression — BLOOD_Leukemia

Explore this box plot interactively →