TCF21

Across TCGA patient cohorts, TCF21 mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF21-associated genes across cancer lineages are MIR3929, PPP3R2, and MIR194-1. Each is linked with TCF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF21-to-partner and partner-to-TCF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3929 grouped by TCF21-low versus TCF21-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF21→partner) and Y-score (partner→TCF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR3929 →	+1.002	+6.008	<.001	.002	3	2
HNSC	PPP3R2 →	+0.046	+3.866	<.001	.008	3	2
HNSC	MIR194-1 →	+0.627	+3.541	<.001	.005	3	2
HNSC	SLC25A5P4 →	+0.068	+3.840	<.001	.002	3	2
HNSC	RN7SKP242 →	+0.092	+5.623	<.001	.001	3	2
CESC	NCOR1P1 →	+0.077	+4.757	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

MIR3929 by TCF21 expression — LIHC

Explore this box plot interactively →