TCF21

Across TCGA pan-cancer cohorts, TCF21 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TCF21 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TCF21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCF21 expression acts as an unfavorable survival marker, although some lineages such as LIHC and KIRC show a favorable association.

LUSC, KIRP, and LIHC are the cancer types where TCF21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	All	0.263	0.492	<.001	67	view →
KIRP	OS	Tertile	II,III,IV	0.223	0.742	<.001	56	view →
LIHC	OS	Median	All	0.840	0.709	<.001	51	view →
KIRC	DFS	Quartile	All	0.852	0.477	<.001	38	view →
LUAD	OS	Quartile	II,III,IV	0.926	0.675	.005	24	view →
CHOL	DFS	Median	All	0.658	0.190	.007	21	view →
BRCA	OS	Tertile	II,III,IV	0.494	0.642	.014	18	view →
LGG	DFS	Tertile	All	0.574	0.759	.001	18	view →
UCS	DFS	Tertile	II,III,IV	0.513	0.179	.006	12	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	12	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	12	view →
LAML	DFS	Median	All	0.730	0.461	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TCF21–LUSC (DFS)

Open the LUSC breakdown →