TCF21

Across TCGA cell cohorts, TCF21 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF21-associated genes across cancer lineages are FCN2 and HSFY2. Each is linked with TCF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF21-to-partner and partner-to-TCF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by TCF21-low versus TCF21-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF21→partner) and Y-score (partner→TCF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.052	+5.415	<.001	.004	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

FCN2 by TCF21 expression — LARGE_INTESTINE

Explore this box plot interactively →