TCF15

Across TCGA pan-cancer cohorts, TCF15 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TCF15 data layer compared with 1 for mutation status.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher TCF15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCF15 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

LAML, KIRP, and OV are the cancer types where TCF15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.203	0.512	<.001	54	view →
KIRP	OS	Tertile	All	0.873	0.985	<.001	51	view →
OV	OS	Quartile	All	0.583	0.753	<.001	48	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
UCEC	DFS	Median	IV	0.724	0.283	.005	20	view →
LUSC	DFS	Tertile	II,III,IV	0.875	0.401	.003	18	view →
KICH	DFS	Median	II,III,IV	0.954	0.730	.024	17	view →
STAD	OS	Tertile	II,III,IV	0.400	0.650	.011	12	view →
COAD	OS	Median	IV	0.373	0.695	.017	9	view →
LIHC	DFS	Median	II,III,IV	0.248	0.424	.013	9	view →
ACC	OS	Median	II,III,IV	0.777	0.924	.009	9	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TCF15–LAML (DFS)

Open the LAML breakdown →