TCF15

Across TCGA pan-cancer cohorts, TCF15 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TCF15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TCF15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TCF15 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where TCF15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCF15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.631	<.001	10	view →
LIHC	Female	II,III,IV	+1.025	<.001	9	view →
BRCA	All	All	−1.067	<.001	6	view →
LUAD	Female	II,III,IV	−0.657	<.001	6	view →
LUSC	All	II,III,IV	+0.873	<.001	5	view →
KICH	Male	All	−0.720	<.001	5	view →
KIRC	Female	III,IV	+0.714	<.001	5	view →
BLCA	All	All	+0.806	.018	2	view →
KIRP	All	All	−0.359	.002	2	view →
THCA	All	All	+0.316	.004	2	view →
CHOL	All	All	+0.302	.020	2	view →
READ	Female	All	−0.639	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TCF15–HNSC

Open the HNSC breakdown →