TCF12

Across TCGA patient cohorts, TCF12 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF12-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and FASN. Each is linked with TCF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCF12-to-partner and partner-to-TCF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TCF12-low versus TCF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF12→partner) and Y-score (partner→TCF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.545	+2.107	.005	.002	3	3
UCEC	Cyclin-B1 →	+0.789	+2.263	<.001	<.001	3	2
UCEC	FASN →	+0.305	+2.459	.018	.018	3	2
UCEC	FOXO3a_pS318_S321 →	-0.128	-1.653	.001	.010	3	2
UCEC	JNK2 →	+0.200	+1.938	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.168	-2.150	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by TCF12 expression — UCEC

Explore this box plot interactively →