TCF12

Across TCGA pan-cancer cohorts, TCF12 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TCF12 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TCF12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCF12 expression acts as an unfavorable survival marker, although some lineages such as LGG and GBM show a favorable association.

UVM, LGG, and ACC are the cancer types where TCF12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.186	0.848	<.001	74	view →
LGG	DFS	Median	All	0.446	0.307	<.001	36	view →
ACC	DFS	Tertile	All	0.389	0.787	<.001	30	view →
GBM	OS	Median	All	0.224	0.153	.015	27	view →
BLCA	DFS	Median	All	0.188	0.490	.008	24	view →
MESO	DFS	Tertile	II,III,IV	0.322	0.669	.012	24	view →
SARC	OS	Tertile	All	0.417	0.783	.002	19	view →
LUSC	DFS	Median	III,IV	0.250	0.526	.006	19	view →
BRCA	DFS	Quartile	III,IV	0.942	0.778	.001	19	view →
DLBC	DFS	Quartile	III,IV	0.203	0.984	.020	18	view →
CESC	DFS	Quartile	All	0.459	0.681	.026	16	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TCF12–UVM (DFS)

Open the UVM breakdown →