TCF12

Across TCGA cell cohorts, TCF12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,992 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TCF12-associated GO terms across cancer lineages are Regulation of heterochromatin organization, Subtelomeric heterochromatin formation, and Response to gonadotropin-releasing hormone. Each is linked with TCF12 in more than 14 cancer types. Because this analysis shows association rather than direction, both TCF12-to-partner and partner-to-TCF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin organization grouped by TCF12-low versus TCF12-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF12→partner) and Y-score (partner→TCF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of heterochromatin organization →	+0.119	+0.879	<.001	<.001	3	15
STOMACH	Subtelomeric heterochromatin formation →	+0.101	+1.200	<.001	<.001	3	14
OVARY	Response to gonadotropin-releasing hormone →	+0.690	+0.854	.003	<.001	3	14
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.075	+1.620	<.001	<.001	3	14
SOFT_TISSUE	Heterochromatin formation →	+0.082	+1.484	<.001	<.001	3	14
BLOOD_Lymphoma	Negative regulation of transcription by RNA polymerase I →	+0.116	+1.422	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,992 associations by consensus.

Regulation of heterochromatin organization by TCF12 expression — LUNG_SCLC

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