TCF12

Across TCGA cell cohorts, TCF12 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF12-associated genes across cancer lineages are TBC1D21, GP9, and BPY2. Each is linked with TCF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF12-to-partner and partner-to-TCF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by TCF12-low versus TCF12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF12→partner) and Y-score (partner→TCF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GP9 →	+0.066	+3.518	.004	.001	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2B →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2C →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SMIM33 →	+0.579	+3.426	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TBC1D21 by TCF12 expression — LARGE_INTESTINE

Explore this box plot interactively →