TCEAL1

Across TCGA patient cohorts, TCEAL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCEAL1-associated genes across cancer lineages are ATM, EGFR_pY1068, and EGFR_pY1173. Each is linked with TCEAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCEAL1-to-partner and partner-to-TCEAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TCEAL1-low versus TCEAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCEAL1→partner) and Y-score (partner→TCEAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.551	-2.584	.009	.011	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.584	.031	.011	3	1
UCEC	EGFR_pY1173 →	+0.075	+1.901	.044	.031	3	1
UCEC	JNK2 →	+0.360	+3.026	<.001	.018	3	1
UCEC	Notch1 →	+0.221	+3.183	<.001	.009	3	1
UCEC	PCNA →	+0.295	+2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by TCEAL1 expression — UCEC

Explore this box plot interactively →