TCAP

Across TCGA patient cohorts, TCAP mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. CESC shows the largest number of these associations.

The most reproducible TCAP-associated genes across cancer lineages are MTCO2P31, LCE4A, and USP9YP2. Each is linked with TCAP in more than 1 cancer types. Because this analysis shows association rather than direction, both TCAP-to-partner and partner-to-TCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P31 grouped by TCAP-low versus TCAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCAP→partner) and Y-score (partner→TCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTCO2P31 →	+0.426	+3.717	<.001	.005	3	2
UCEC	LCE4A →	+0.052	+4.877	<.001	.003	3	2
BLCA	USP9YP2 →	+0.039	+7.640	<.001	.009	3	2
PRAD	RNU6-1060P →	+0.568	+7.939	<.001	.008	3	1
PRAD	TRIM64EP →	+0.068	+7.939	<.001	.008	3	1
PRAD	TRAPPC2P3 →	+0.129	+7.939	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

MTCO2P31 by TCAP expression — UCEC

Explore this box plot interactively →