TCAP

Across TCGA pan-cancer cohorts, TCAP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TCAP’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where TCAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TCAP is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

STAD, HNSC, and LUAD are the cancer types where TCAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	+0.608	<.001	9	view →
HNSC	Male	All	−3.083	.002	8	view →
LUAD	Male	All	−0.791	<.001	7	view →
LUSC	All	II,III,IV	−0.621	<.001	6	view →
COAD	All	All	+0.215	.005	6	view →
LIHC	All	All	+0.558	<.001	4	view →
PRAD	All	All	−1.265	<.001	2	view →
READ	All	All	+0.355	.018	2	view →
ESCA	Male	All	+0.934	.049	1	view →
CHOL	All	All	+0.705	.031	1	view →
KIRC	All	II,III,IV	−0.154	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TCAP–STAD

Open the STAD breakdown →