TBXA2R

Across TCGA pan-cancer cohorts, TBXA2R mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TBXA2R’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBXA2R mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TBXA2R is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where TBXA2R tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBXA2R mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.478	<.001	9	view →
LSCC	Male	II,III,IV	+0.378	<.001	7	view →
CCRCC	All	All	+0.167	.010	2	view →
PDAC	Male	III,IV	−0.533	.049	1	view →
LUAD	Male	III,IV	+0.399	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TBXA2R–HNSC

Open the HNSC breakdown →