TBXA2R

Across TCGA pan-cancer cohorts, TBXA2R RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TBXA2R data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TBXA2R RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBXA2R expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

MESO, ACC, and KIRC are the cancer types where TBXA2R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.247	0.522	<.001	144	view →
ACC	OS	Median	All	0.779	0.958	<.001	137	view →
KIRC	DFS	Median	All	0.722	0.528	<.001	117	view →
KIRP	DFS	Median	All	0.494	0.933	<.001	81	view →
LUSC	DFS	Median	II,III,IV	0.306	0.502	.001	45	view →
CESC	DFS	Median	All	0.649	0.822	<.001	42	view →
UVM	DFS	Quartile	All	0.527	0.911	.003	35	view →
BRCA	DFS	Quartile	All	0.860	0.913	.013	23	view →
LUAD	OS	Median	II,III,IV	0.589	0.324	.001	13	view →
HNSC	OS	Tertile	All	0.309	0.464	.011	13	view →
PAAD	OS	Median	All	0.510	0.296	.003	12	view →
OV	OS	Tertile	All	0.808	0.880	.037	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TBXA2R–MESO (OS)

Open the MESO breakdown →