TBXA2R

Across TCGA patient cohorts, TBXA2R mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TBXA2R-associated genes across cancer lineages are MEK1, Caspase-8, and GSK3-a-b. Each is linked with TBXA2R in more than 1 cancer types. Because this analysis shows association rather than direction, both TBXA2R-to-partner and partner-to-TBXA2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TBXA2R-low versus TBXA2R-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXA2R→partner) and Y-score (partner→TBXA2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.284	+2.824	.009	.034	3	2
UCEC	Caspase-8 →	-0.329	-3.295	.006	.009	3	2
COAD	GSK3-a-b →	+0.191	+2.849	.022	.034	3	1
COAD	XBP1 →	+0.242	+2.815	.020	.036	3	1
COAD	B-Raf →	+0.438	+2.832	.029	.035	2	2
UCEC	S6_pS240_S244 →	+0.504	+3.169	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by TBXA2R expression — COAD

Explore this box plot interactively →