TBX4

Across TCGA patient cohorts, TBX4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,231 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX4-associated genes across cancer lineages are UPB1, CENPM, and CHRDL1. Each is linked with TBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX4-to-partner and partner-to-TBX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX4 versus UPB1 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX4→partner) and Y-score (partner→TBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UPB1 →	+0.209	+0.845	<.001	<.001	3	2
LSCC	CENPM →	-0.514	-0.442	<.001	<.001	3	2
LSCC	CHRDL1 →	+1.029	+0.520	<.001	<.001	3	2
LUAD	RGCC →	+0.542	+0.418	.003	.001	3	2
LSCC	NCAPD2 →	-0.422	-0.405	.002	.001	3	2
LSCC	DNAJC2 →	-0.416	-0.447	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,231 associations by consensus.

TBX4 vs UPB1 — LSCC

Explore this scatter interactively →