TBX4

Across TCGA pan-cancer cohorts, TBX4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TBX4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TBX4 RNA is repressed in tumor relative to normal tissue. In most cancer types TBX4 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, KIRC, and LUSC are the cancer types where TBX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.642	<.001	11	view →
KIRC	All	III,IV	+0.103	<.001	10	view →
LUSC	Female	II,III,IV	−3.564	<.001	9	view →
BLCA	All	III,IV	−2.213	<.001	8	view →
HNSC	Male	All	+0.615	<.001	8	view →
LIHC	All	All	+0.565	.003	6	view →
BRCA	All	III,IV	−0.284	<.001	4	view →
THCA	Male	IV	−0.116	<.001	4	view →
KIRP	All	All	+0.080	.007	4	view →
STAD	All	All	+0.393	.028	3	view →
COAD	All	All	+0.251	.005	3	view →
PRAD	All	All	−1.417	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TBX4–LUAD

Open the LUAD breakdown →