TBX4

Across TCGA patient cohorts, TBX4 mutation is significantly associated with the RNA expression of many other genes, with 3,442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX4-associated genes across cancer lineages are RTTN, SBF2-AS1, and ENG. Each is linked with TBX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX4-to-partner and partner-to-TBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTTN grouped by TBX4-low versus TBX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX4→partner) and Y-score (partner→TBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RTTN →	+0.615	+3.716	<.001	<.001	3	3
UCEC	SBF2-AS1 →	+0.556	+3.456	<.001	<.001	3	3
UCEC	ENG →	-0.469	-2.183	.002	.002	3	3
UCEC	OTX1 →	+0.700	+2.939	.001	<.001	3	3
UCEC	MRPL37 →	+0.481	+2.736	.001	<.001	3	3
UCEC	MMACHC →	+0.365	+2.254	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,442 associations by consensus.

RTTN by TBX4 expression — UCEC

Explore this box plot interactively →